The main road in the eastern part of Khatlon goes from Dushanbe to Norak to Danghara to Kulob:
Note: Vladimir Varfolomeev has a full album of photos from the 1990s, many of them from Khatlon Province.
Aside from spending a few minutes to take a roadside photo, there are some destinations that are worth an hour or more of your time. The best thing to do is to visit during the spring when the hills are an emerald green and flowers are blooming. This photo, from a full album by kt, is a good example of spring: