The main road that heads south from Dushanbe leads to Qurghonteppa, Sarband, Panj, Qubodiyon, Shahrtuz, and several other towns in the south. It is also an alternate route to Danghara, Kulob and other points further east.
If you know where to look, there are some interesting and scenic stops along the way.
There are several signs and monument that are easy to stop at for a quick photo.
In addition to the usual roadside livestock (cattle, sheep, horse and goats), you may even spot some friendly wildlife.
The most popular itinerary for a road trip in this direction would be Dushanbe to 44 Springs (Chiluchor Chashma):